The objective of this study was to investigate the antiulcer activity of leaves of Leptadenia reticulata Linn. (Asclpiadaceae) in rats. Fresh dried leaves of Leptadenia reticulata were extracted by maceration method. Antiulcer activity of the aqueous extract at two concentrations 100 and 200 mg/kg were evaluated in rats using ethanol, indomethacin and pylorus ligation induced ulcer models. Famotidine as Standard drug. The evaluated parameters are ulcer index, acid volume, pH and total acidity. The extract (100 mg/kg & 200 mg/kg) showed significant (P<0.001) reduction in acid volume, total acidity and ulcer index as compared to control. This present study indicates that Leptadenia reticulata leaves aqueous extract have potential anti ulcer activity in all the models.
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